Paracetamol and Diclofenac

Indication

It is indicated for the acute and chronic treatment of signs and symptoms of osteoarthritis and Chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis. It is also indicated for the treatment of ankylosing spondylitis, management of pain and primary dysmenorrhea, when prom...read more

Dosage and Administration

Adult: 1 to 2 tablets, 3-4 times a day or as recommended by Healthcare Professionals.

Composition

Each tablet contains:

Paracetamol B.P……………… 500 mg

Diclofenac Sodium B.P ……….. 50 mg.

Description

Paracetamol is N-acetyl para-amino phenol derivatives. It is non-steroidal anti-inflammatory drug and it has analgesic, antipyretic and weak anti-inflammatory activity. Chemical formula is C8H9NO2 and its molecular weight is 151.2. Diclofenac Sodium is a phenylacetic acid derivative and non-steroida...read more

Clinical Pharmacology

Paracetamol is also known as acetaminophen. It is inhibitor of the enzyme cyclo-oxygenase and inhibits the synthesis of prostaglandins in the central nervous system and peripherally blocks pain impulse generation; produces antipyresis from inhibition of hypothalamic heat-regulating center. Therefor...read more

Pharmacokinetics

Paracetamol is readily absorbed from the GI tract. Peak plasma concentration occurs at 10 – 60 minutes after oral dose. It is distributed into most body tissues. It crosses the placenta and present in breast milk. Plasma protein binding is negligible at usual therapeutic concentration but increase w...read more

Contraindication

It is contraindicated in patients who have known hypersensitivity to diclofenac or acetaminophen and diclofenac and acetaminophen containing products and should not be given to patients who have experienced active peptic ulcer or GI bleeding, history of allergic responses to aspirin or other NSAIDs,...read more

Warnings and Precautions

It should be given with care to patients with analgesic nephropathy, renal or hepatic impairment, hypertension, cardiac failure, bronchospasm and patients taking diuretics. It should not be administered during pregnancy or lactation and elderly. It is not recommended for children aged under 14.

Adverse Effects

Common side effects are GI disturbances, nephrotic syndrome, epigastric pain, nausea, vomiting, diarrhoea, hepatitis, rash, pruritus, wheezing, bronchospasm, prolonged bleeding time. Potentially Fatal: Bleeding or perforation through peptic ulcer, rarely blood dyscrasia or anaphylaxis, acute ren...read more

Drug Interaction

Potentiates potassium-sparing diuretics. Reduced serum levels of salicylates. Potentially Fatal: Increased levels of lithium, digoxin and methotrexate.

Storage

Store below 30°C in cool and dry place. Protect from light and moisture. Keep out of reach and sight of children.

Presentation

10 x 10’s Blisters