Norfloshin
Norfloxacin
Indication
It is used in the treatment of urinary tract infections, urethritis and/or cervicitis, bacterial enteric infections and prophylaxis in granulocytopenic patients.
Dosage and Administration
Uncomplicated Lower Urinary Tract Infections: 400 mg twice daily for 3 - 10 days.
Urinary Tract Infections: 400 mg twice daily for 7 - 10 days.
Chronic Relapsing Urinary Tract Infections: 400 mg twice daily up to 12 weeks.
Gonococcal Urethritis or Cervicitis: A single dose of 800 mg.
Renal Impairment: Dosage should be modified in renal impairment by giving a 400 mg daily dosage. Maximum Recommended Dose: 400 mg twice daily.
Take Norfloxacin at least one hour before or 2 hours after a meal or having milk or other dairy products.
Composition
Each film-coated caplet contains
Norfloxacin B.P ... 400 mg.
Description
Norfloxacin is a synthetic, broad-spectrum antibacterial agent for oral administration. Norfloxacin, fluoroquinolone, is 1-Ethyl-6-fluoro-4-oxo-7-( piperazin-1-yl)-1, 4-dihydroquinoline-3-carboxylic acid. Its empirical formula is C16H18FN3O3 and molecular weight is 319.3.
Clinical Pharmacology
The bactericidal action of Norfloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination. Norfloxacin is a broad-spectrum antibiotic agent that is shown to be effective...
Pharmacokinetics
Absorption of norfloxacin is rapid following single doses of 200 mg, 400 mg and 800 mg. At the respective doses, mean peak serum and plasma concentrations of 0.8, 1.5 and 2.4 µg/mL are attained approximately one hour after dosing. The effective half-life of norfloxacin in serum and plasma is 3-4 hou...
Biotransformation is via the liver and kidneys, with a half-life of 3 – 4 hours.
Contraindication
Norfloxacin is contraindicated in persons with a history of hypersensitivity, tendinitis or tendon rupture associated with the use of norfloxacin or any member of the quinolone group of antimicrobial agents.
Precaution
Fluoroquinolones, including Norfloxacin, have been associated with disabling and potentially irreversible serious adverse reactions from different body systems that can occur together in the same patient. Commonly seen adverse reactions include tendinitis, tendon rupture, arthralgia, myalgia, periph...
Adverse Effects
Common side effects are nausea, headache and dizziness. Usually, these side effects are mild. Severe abdominal cramps, watery and severe diarrhea, which may also be bloody and fever, in combination with one or both of the above can sometimes occur but rare.
Drug Interaction
Multivitamins, other products containing iron or zinc, antacids containing magnesium and aluminium, sucralfate, or chewable/buffered tablets or the pediatric powder for oral solution, should not be taken within 2 hours of administration of norfloxacin. Concomitant use with drugs metabolized by CYP1A...
Storage
Store below 30ºC in cool and dry place. Protect from light and moisture. Keep out of reach and sight of children.
Presentation
10 x 10’s Blisters.