Furoshin
Furosemide
Indication
Treatment of edema and hypertension.
Dosage and Administration
Adult: For the treatment of diuresis, the usual oral dose is 1/2-2 tablets given as a single dose, preferably in the morning. Avoid taking within 4 hours of bedtime to prevent night-time urination.
Depending on the patient's response, a 2nd dose of 1/2-1 tablet can be administered 6-8 hrs later until the desired response is obtained. For the treatment of hypertension, the usual dose is 1 tablet for initiating therapy and for maintenance.
Children: 1-3 mg/kg body weight daily.
Composition
Each tablet contains:
Furosemide B.P ........ 40 mg.
Description
Furosemide is a loop diuretic agent. Chemically, it is 4-Chloro-2-[[(furan-2-yl)methyl]amino]-5-sulfamoylbenzoic acid. Its molecular formula is C12H11ClN2O5S and its molecular weight is 330.7.
Clinical Pharmacology
Furosemide is one of the most potent diuretics. It generally produces an adequate increase in sodium and water excretion even in cases in which diuresis cannot be increased in other ways. It is effective even in patient with considerably impaired glomerular filtration, hypoalbuminaemia or metabolic...
Pharmacokinetics
Increased urinary excretion usually begins within the 1st hour after ingestion of 40 mg tablets and last for an average of 6-8 hrs. Duration and intensity of diuresis may vary in different patients. In the early phases of treatment, a more pronounced effect is to be excepted.
Contraindication
Furosemide is contraindicated in patients with anuria and those receiving lithium therapy. Contraindicated for further use if increasing azotemia and/or oliguria occur during the treatment severe, progressive renal disease.
Precaution
Furosemide may provoke hyperglycaemia and glycosuria, thus exercise care when giving diabetic patients. It may cause hyperuricaemia and precipitate attacks of gout in some patients, it should be used in patients with prostatic hypertrophy or impairment of micturition. Patients with known sensitivity...
Adverse Effects
Furosemide may cause azotemia, hyperuricaemia and hyperglycaemia. Bone marrow depression has been reported as a rare complication of furosemide therapy which necessitates withdrawal of treatment. Dermatological reactions have been reported with the use of furosemide, including urticaria, erythem...
Haematological disturbance with furosemide include anaemia agranulocytosis and thrombocytopenia. Allergic intestitial nephritis and acute pancreatitis have been reported rarely.
Other reactions, usually reversible upon discontinuance of furosemide, have been reported, including tinnitus and reversible deafness, paresthesia, blurred vision, postural hypotension and GI intolerance.
Overdose
Overdose will lead to fluid and salt depletion subsequent to excessive diuresis. Medical help must be called in without delay so as to ensure immediate measures for an adequate restoration of water and electrolyte balances.
Drug Interaction
Concomitant administration of furosemide and most other diuretics results in enhanced effects, hence the dose of furosemide should be reduced in such circumstances. In patients receiving digitalis glycosides, electrolyte disturbances produced by furosemide predispose the patient to digitalis toxicit...
Furosemide may enhance the nephrotoxicity of cephaloridine, aminoglycosides antibiotics, e.g. gentamicin, neomycin and streptomycin.
Patients receiving chronic anticonvulsant therapy and those on aspirin and other anti-inflammatory analgesics have been shown to have a diminished diuretic effect of furosemide. Furosemide is known to interact with lithium, causing reduced renal clearance of lithium, antidiabetic agents and hypotens...
Storage
Store below 30°C in cool and dry place. Protect from light and moisture. Keep out of reach and sight of children.
Presentation
10 x 10’s Blisters.