Azithroshin
Azithromycin 250/ 500
Indication
Azithromycin is indicated in the upper respiratory tract infections (eg, sinusitis, pharyngitis, tonsillitis); lower respiratory tract infections (eg, acute bronchitis and mild to moderately severe community acquired pneumonia) and acute otitis media; skin and soft tissue infections; uncomplicated C...
Dosage And Administration
Respiratory-tract infection, otitis media, skin and soft-tissue infections
Child 6 months-17 years: 10 mg/kg once daily (max: per dose 500 mg) for 3 days
Adult: 500 mg once daily for 3 days,alternatively initially 500 mg once daily for 1 day ,then 250 mg once daily for 4 days.
Uncomplicated genital chlamydial infections/ Non-gonococcal urethritis
Child 12-17 years : 1g for 1 dose Adult : 1g for 1 dose
Community- acquired pneumonia, low to moderate severity
Adult : 500 mg once daily for 3 days, alternatively
initially 500 mg once daily for 1 day, then 250 mg once daily for 4 days
Children: Use of azithromycin in children < 6 months is not recommended.
Composition
Each film-coated caplet contains:
Azithromycin Dihydrate equivalent to Azithromycin ... 250 mg / 500 mg.
Description
Azithromycin is a macrolide antibiotic belonging to the azalide group. The molecule is constructed by adding a nitrogen atom to the lactone ring of erythromycin A. Its molecular formula is C38H72N2O12.2H2O. Its molecular weight is 785.02.
Clinical Pharmacology
The mechanism of action of azithromycin is based upon the suppression of bacterial protein synthesis by means of binding to the ribosomal 50s sub-unit and inhibition of peptide translocation.
Microbiological Action: It is active against gram-positive bacteria: Staphylococcus aureus, Streptococcus spp. (including Streptococcus pneumoniae, Streptococcus pyogenes group A); gram- negative bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhali...
Pharmacokinetics
Azithromycin is rapidly absorbed from the gastrointestinal tract. Ingestion reduces the absorption of azithromycin. Peak plasma concentration( Cmax) is reached after 2-3 hrs. It is also rapidly distributed in tissues and biological fluids. The Protein binding (concentration dependent) is 7% to 50%. ...
Contraindication
Hypersensitivity to azithromycin, other macrolide antibiotics, or any component of the formulation.
Precaution
Use with caution in patients with hepatic dysfunction; hepatic impairment with or without jaundice has occurred chiefly in older children and adults; it may be accompanied by malaise, nausea, vomiting, abdominal colic, and fever; discontinue use if these occur, may mask or delay symptoms of incuba...
Adverse Effects
The common side effects are diarrhea, nausea, abdominal pain, cramping, vomiting (especially with high single-dose regimens).
Drug Interactions
Antacids: Peak serum levels but not the total extent of absorption were reduced by the presence of magnesium- and aluminium- containing antacids in the stomach. Azithromycin should be taken at least 1hr before or 2hrs after these antacids.
Ergot Derivatives: In patients receiving ergot alkaloids, azithromycin should be avoided concurrently because of the possibility of ergotism resulting from interaction of azithromycin with the cytochrome P 450 system.
Digoxin and Cyclosporine: Macrolides have been known to increase the plasma concentrations of digoxin in (by altering the gut flora) and cyclosporine (by inhibition of metabolism). Therefore, if co-administration is necessary, caution should be exercised, and serum levels of digoxin and cyclosporine...
Storage
Store below 30˚C in cool and dry place. Protect from light and moisture. Keep out of reach and sight of children.
Presentation
10 x 3’s Blisters